Their structures were determined by UV, IR, HR-ESI-MS, ESI-MS, 1D- and 2D-NMR techniques.”
“OBJECTIVE: To estimate the
effect of first-trimester influenza vaccination on fetal and neonatal outcomes.
METHODS: This was a retrospective cohort study examining delivery and neonatal outcomes after antepartum exposure to the seasonal trivalent inactive influenza vaccine. Data were collected and entered into an established computerized database. Outcomes by trimester of vaccination were then compared with women who did not receive the vaccine.
RESULTS: During the 5-year study period, 10,225 women received the seasonal influenza vaccine antepartum; 8,690 of these MDV3100 purchase delivered at our institution, 439 in the first trimester and 8,251 Nutlin-3 clinical trial in the second and third trimesters. Women vaccinated antepartum were significantly older with higher parity than women who declined
vaccination. Neonates born to mothers receiving the vaccine in any trimester did not have an increase in major malformations regardless of trimester of vaccination (2% regardless of vaccination group, P=.9). Stillbirth (0.3% compared with 0.6%, P=.006), neonatal death (0.2% compared with 0.4%, P=.01), and premature delivery (5% compared with 6%, P=.004) were significantly decreased in the vaccinated group.
CONCLUSION: Influenza vaccination in the first trimester was not associated with an increase in major malformation rates and was associated with a decrease in the overall stillbirth rate. This information will aid in counseling women regarding the safety of influenza vaccination in the first trimester. (Obstet Gynecol 2012; 120: 532-7) DOI: http://10.1097/AOG.0b013e318263a278
LEVEL OF EVIDENCE: II”
“The phytochemical investigation of the stem bark of Tinospora cordifolia Miers (Menispermaceae) has afforded four new compounds, named tinosporafuranol, tinosporafurandiol, tinosporaclerodanol, and tinosporaclerodanoid, along with -sitosterol, and their stereostructures have been elucidated correspondingly as 4-seco-cleroda-19-ol-13-furanoid, 4-seco-cleroda-6-en-18,19-diol-13-furanoid,
cleroda-1(10)-en-6-ol and cleroda-1-one-2-en-11,15,16,18-tetraol-12,19-olide on the basis of spectral data analyses and chemical reactions.”
“OBJECTIVE: Neonatal brachial plexus palsy frequently is described in conjunction with shoulder dystocia complicating MK-2206 nmr a vaginal delivery. In this study, we present a series of cases of severe brachial plexus palsy that occurred without shoulder dystocia.
METHODS: Cases were identified from deliveries at the Los Angeles County and University of Southern California Medical Center. Various maternal and neonatal characteristics were analyzed.
RESULTS: Eight cases without shoulder dystocia but with severe brachial plexus palsy requiring neonatal intensive care unit admission were identified. None of the patients had maternal diabetes, previous shoulder dystocia, previous macrosomia, or labor induction. The mean second stage of labor was normal (2.15 +/- 1.