Optical AG-881 mw detection of acoustic waves enables working with acoustic frequencies higher than 107 Hz and allows characterization of transparent films of submicron thickness. Pilot measurements have been carried out with SiO(2) films on monocrystalline silicon wafer. Thermal diffusivity determined in the experiment agrees with the reference value for the bulk fused quartz. (c) 2009 American Institute of Physics. [DOI: 10.1063/1.3131662]“
“Survivin is a well-established target in experimental cancer therapy. The molecule is over-expressed in most human tumors, but hardly detectable in normal tissues. Multiple

functions in different subcellular compartments have been assigned. It participates in the control of cell division, apoptosis, the cellular stress response, and also in the regulation of cell migration and metastasis. Survivin expression has been recognized as a biomarker: high expression indicates an unfavorable prognosis and resistance to chemotherapeutic agents and radiation treatment. Survivin is an unconventional drug target and several

indirect approaches have been selleck exploited to affect its function and the phenotype of survivin-expressing cells. Interference with the expression of the survivin gene, the utilization of its messenger RNA, the intracellular localization, the interaction with binding partners, the stability of the survivin protein, and the induction of survivin-specific immune responses have been taken into consideration. A direct strategy to inhibit survivin has been based on the identification of a specifically interacting peptide. This peptide can recognize survivin intracellularly and cause the degradation of the ligand-survivin complex. Technology is being

developed that might allow the derivation of small molecular-weight, drug-like compounds that are functionally equivalent to the peptide ligand.”
“The primary objective of our study is to describe urinary symptoms in women treated U0126 research buy for endometrial cancer. We performed a cross-sectional survey of women who had undergone surgical treatment for endometrial cancer. Three validated questionnaires were utilized: the Sandvik Severity Index, the Urinary Distress Inventory-6 (UDI-6), and Incontinence Impact Questionaire-7 (IIQ-7). Our study included 70 women treated for endometrial cancer; 35.7% (25/70) of women reported adjuvant radiation therapy after surgical staging. Urinary incontinence was reported in over 80% of women. Mean UDI-6 and IIQ-7 scores for women treated with adjuvant radiation therapy were higher compared to women with no adjuvant radiation therapy [47(+/- 26.8) vs. 35.6(+/- 21.7; p = 0.05)] and [24.4(+/- 28.5) vs. 8.1(+/- 16.4; p = 0.004)], respectively. Treatment with adjuvant radiation therapy was associated with more severe incontinence symptoms and impact on quality of life.”
“Background: Elderly heart failure (HF) patients frequently have multiple comorbidities.