Dyspnée, altération de la performance à l’exercice • Bronchodilatateurs de courte durée d’action (BDCA) à la demande. Exacerbations • BDLAs Insuffisance respiratoire chronique • Oxygénothérapie de longue durée. Verteporfin cost les auteurs n’ont pas transmis de déclaration de conflits d’intérêts. Source de financement :

aucune. “
“The antimuscarinic drug tolterodine tartarate (TL) is chemically (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine l-hydrogen tartarate (Fig. 1), is used to treat urinary incontinence.1 TL having a high binding affinity for the cholinergic muscarinic receptors that mediates contraction there by in controls the hyperactive the urinary bladder and prevent the frequent urinations.2 TL does not caused any side effects such as dry mouth, constipation and urine retention like other muscarinics.3 We found following methods were reported for the estimation TL either

in biological matrix or in pharmaceutical formulation both individual and combined are UV and visible spectrophotometric methods,4, 5, 6, 7 and 8 HPLC,9 HPLC–mass spectrometry,10 and 11 capillary chromatography,12 and 13 chiral HPLC,14 HPTLC,15 UPLC16 and potentiometric determinations using ion selective electrodes17 for the estimation of TL and its metabolite. Even though the regular sophisticated methods and such as HPLC and LC–MS/MS are more accurate to estimate the drug in nano gram level, they need complex sample treatment and expensive solvents and reagents for analysis. Hence, the spectrophotometric methods still keep their credential Proteasome function role in drug analysis. UV methods are very simpler than any other methods but they too lack in specificity, they easily affected even by a small amount of UV sensitive solvents or excipients used in formulations but the specificity of visible methods are found to be more than UV by the use of specific reagents suitable to produce chromogen with target analyte because. these Among the colorimetric methods of estimation the extractive colorimetric methods are more easy handle and needs less reagents, solution, solvents and non hazardous. In pharmaceuticals many extractive colorimetric

methods were reported as in the name of ion-association and ion-pair complex.18, 19, 20, 21 and 22 To the best of our knowledge none of the researchers were reported the estimation of TL using ion-pair complex formation using methyl orange. Hence, in the present study a quantitative ion-pair extractive colorimetric analysis of TL using MO was commenced. The main aim of the present report was to accomplish a simple, accurate, precise and validated extractive colorimetric method for the determination of TL and its checks suitability for assaying the TL content in formulations according to the requirements of United States Pharmacopeia (USP) and International Conference on Harmonization (ICH) guidelines for method validation.