Changes In pH and sheet size can tune the amphiphilicity of GO, leading to intriguing interfacial activities. In addition, new all-carbon composites made of only graphitic nanostructures selleck using GO as a dispersing agent have potential applications in photovoltaics CX-4945 solubility and energy storage. On the other hand, GO can function as a 2D random diblock copolymer, one block graphitic and the other heavily hydroxylated. Inhibitors,Modulators,Libraries Therefore, GO can guide material assembly through pi-pi stacking and hydrogen bonding. Additionally, the selective etching of the more reactive sp(3) blocks produces Inhibitors,Modulators,Libraries a porous GO network, which greatly enhances interactions with gas molecules in chemical sensors. With their high aspect ratio, GO colloids can readily align to form liquid crystalline phases at high concentration.
As single-atomic, water-dispersible, soft carbon sheets that can be easily converted to a conductive form, this 20 material should continue to inspire many Inhibitors,Modulators,Libraries curiosity-driven discoveries and applications at the interfaces of chemistry, materials science, Inhibitors,Modulators,Libraries and other disciplines.”
“Carbon-heteroatom bonds (C-X) are ubiquitous and are among the most reactive components of organic compounds. Therefore investigations of the construction of C-X bonds are fundamental and vibrant fields in organic chemistry. Transition-metal-catalyzed heteroatom-hydrogen bond (X-H) Insertions via a metal carbene or carbenoid intermediate represent one of the most efficient approaches to form C-X bonds.
Because of the availability of substrates, neutral and mild reaction conditions, Inhibitors,Modulators,Libraries and high reactivity of these transformations, researchers have widely applied transition-metal-catalyzed X-H insertions in organic synthesis.
Researchers have developed a variety of rhodium-catalyzed asymmetric Inhibitors,Modulators,Libraries C-H insertion Inhibitors,Modulators,Libraries reactions with high to excellent enantioselectivities for a wide range of substrates. However, at the time that we launched our research, very few highly enantioselective X-H insertions had been documented primarily Inhibitors,Modulators,Libraries because of a lack of efficient chiral catalysts and indistinct insertion mechanisms.
In this Account, we describe our recent studies of copper- and iron-catalyzed asymmetric X-H insertion reactions by using chiral spiro-bisoxazoline and diimine ligands.
Inhibitors,Modulators,Libraries The copper complexes of chiral Inhibitors,Modulators,Libraries spiro-bisoxazoline ligands proved to be highly enantioselective catalysts for N-H insertions of alpha-diazoesters into anilines, O-H insertions of alpha-diazoesters into phenols and water, O-H insertions of alpha-diazophosphonates into alcohols, and S-H insertions of alpha-diazoesters Into Wnt-C59 dissolve solubility mercaptans. The iron complexes of chiral spiro-bisoxazoline ligands afforded the O-H insertion of alpha-diazoesters into alcohols and water with unprecedented enantioselectivities. The copper complexes of chiral spiro-diimine ligands exhibited excellent reactivity and enantioselectivity in the Si-H insertion of alpha-diazoacetates into a wide selleck inhibitor range of silanes.