Testing Sessions Prior to pre-testing, subjects were instructed to refrain from heavy exercise for 48 hours and fast for at least 12-hours. The assessment of upper body muscular strength (1-RM) and repetitions to failure (RTF) testing was performed after a general warm-up of 3-5

minutes of light activity involving the muscle(s) to be tested (e.g., upper body ergometry prior to upper body strength testing). Next, the subject performed several minutes of static stretching exercises of the involved musculature. The subject then performed a specific CB-839 mouse warm-up set of 8 repetitions at approximately 50% of the perceived 1-RM followed by another set of 3 repetitions at 70% of the perceived 1-RM. Subsequent lifts were single repetitions of progressively heavier weights until failure. The initial increments in weight were evenly spaced and adjusted such that at least two KPT-330 single lift sets was performed between the three repetition warm-up set and the estimated 1-RM. At failure, a weight approximately midway between the last successful and failed lift was attempted. This process was repeated until the 1-RM was determined. The rest interval between sets was between 3-5 minutes (procedure modified from Brown et al., 2001) [6]. Results were obtained at baseline, and at week 3, 6 and 9. For testing at weeks 3, 6 and 9, in order to replicate pre-supplementation/baseline testing conditions as closely as possible,

subjects were instructed to follow their previously recorded 3-day diet records, refrain from heavy exercise for 48 hours, and fast for at least 12-hours prior to the workout. Upper body muscle endurance was measured as the total repetitions completed during three successive sets N-acetylglucosamine-1-phosphate transferase of isotonic bench press at a load equal to 100% subjects’ pre-testing body weight. Each set was separated by a one-minute rest period. Body Composition Assessment Body composition was assessed at baseline, and weeks 3, 6 and 9. Standing height was Idasanutlin determined using a wall-mounted stadiometer. Body weight was measured using a SECA™ Medical Scale. Lean mass and fat mass were assessed using dual energy x-ray absorptiometry

(DEXA, General Electric LUNAR DPX Pro). For each subject, the same technician performed all four DEXA measurements. Supplementation Protocol SOmaxP contains creatine monohydrate (4 g), carbohydrate (39 g), and whey protein (7 g), and a number of proprietary ingredients. Subjects randomized to the SOmaxP group took 1 serving of SOmaxP + 30 ounces of water starting 10-15 minutes before the workout and finishing before the end of the workout, and used the product only on the days when resistance training occurs. The comparator product (CP) was standardized to contain equal amounts of creatine monohydrate (4 g), carbohydrate (39 g maltodextrin) and protein (7 g whey protein), and given with 30 ounces of water, with identical timing, and similarly used only on resistance training days.