We provide a selective review of brain imaging studies and their relevance to mechanisms of cognitive aging first

identified primarily from behavioral measurements. We also examine some new key discoveries. including evidence favoring plasticity and compensation that have emerged specifically from using cognitive neuroscience methods to study healthy aging. click here We then summarize several recent neurocognitive theories of aging, including our own model the Scaffolding Theory of Aging and Cognition. We close by discussing some newly emerging trends and future research trajectories for investigating the aging in and bram.”
“Granulocyte-colony stimulating factor (G-csf) is a member of the hematopoietic growth factor family and demonstrates neuroprotective functions in neurodegenerative diseases. This PF-4708671 concentration study evaluated the radioprotective effects of G-csf in the suppression of hippocampal neurogenesis in adult mice undergoing irradiation. The radioprotective effects were assessed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay and immunohistochemical markers of neurogenesis, including the proliferating cell marker Ki-67 and the immature progenitor neuron marker doublecortin (DCX). Acute exposure to cranial irradiation (5 Gy gamma-rays) induced neural apoptosis and inhibited neurogenesis in the dentate gyrus (DG) of the adult mouse hippocampus. Pretreatment

with G-csf (100 mu g/kg every 12 h subcutaneously on three consecutive days) attenuated neural apoptosis

and decreased the number of Ki-67- and DCX-positive cells in the DG of the irradiated mouse hippocampus. Therefore, G-csf inhibited the detrimental effects of irradiation on hippocampal neurogenesis, suggesting that G-csf administration has potential therapeutic utility in brain irradiation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“We investigated associations between spouses’ shared possible selves and well-being as a function of their perceptions of collaboration in 61 late-midlife MSDC-0160 (M = 60 years) and older (M = 72 years) couples dealing with prostate cancer. Spouses completed assessments of possible selves (with shared selves defined as possible selves portraying a similar goal across spouses), psychological well-being, and enjoyment and frequency of collaboration. Associations between shared selves and better well-being occurred through better enjoyment of collaboration regardless of age (after controlling for marital quality and subjective health). An interaction revealing that shared selves were associated with better well-being only with frequent collaboration was obtained with older couples but was not found in late-mid life couples.”
“Increasing evidence indicates neuroinflammation is instrumental in the pathogenesis of Parkinson’s disease (PD). In PD, there is selective degeneration of neuromelanin (NM)-containing dopamine neurons.