We present here the development of mathematical, time-delay models for protein translation, based on PDE models, which in turn are derived through systematic approximations PP2 of first-principles mechanistic models. Theoretical analysis suggests that the key

features that determine the time-delays and the agreement between the time-delay and the mechanistic models are ribosome density and distribution, i.e., the number of ribosomes on the mRNA chain relative to their maximum and their distribution along the mRNA chain. Based on analytical considerations and on computational studies, we show that the steady-state and dynamic responses of the time-delay models are in excellent agreement with the detailed mechanistic models, under physiological conditions that correspond to uniform ribosome distribution and for ribosome density up to 70%. The methodology presented here can be used for the development of reduced time-delay models of mRNA synthesis and large genetic networks. The good agreement between the time-delay and the mechanistic models will allow us to use the reduced model and advanced computational methods from nonlinear dynamics in order to perform studies that are not

practical using the large-scale mechanistic models.”
“Implementation of the linear electro-optic (EO) effect in LDC000067 supplier thin film waveguides is expected to allow drastic reductions in the drive voltage, power, and dimensions of devices devoted to light modulation. It should also enable the realization of electrically tunable photonic crystal devices. In this paper we introduce a method

which eliminates systematically the sources of the unreliability which strongly affects thin film EO characterization. Based on a Fabry-Perot reflective configuration, the method enables characterizing simultaneously the EO, converse-piezoelectric, and electroabsorptive effects in a film. It provides the magnitude and sign of each of the involved coefficients, and allows accounting for the whole of experimental data versus angle of incidence for both transverse-electric and transverse-magnetic polarizations. At lambda=633 nm and room AZD1152 cost temperature, the results obtained with an epitaxial strontium barium niobate (SrxBa1-xNb2O6, x=0.60) ferroelectric thin film, are: r(13)=+ 8.5 +/- 1.3 pm/V, r(33)=+38.9 +/- 0.5 pm/V, d(33) =Delta e/Delta V=+21 +/- 4 pm/V, and Delta k(o)/Delta V=(+9.8 +/- 0.6) x 10(-6), where r(13) and r(33) are two linear EO coefficients, d(33) is a converse-piezoelectric coefficient, and e, k(o), V represent, respectively, the film thickness, film ordinary extinction coefficient, and applied voltage. Converse-piezoelectric and electroabsorptive effects are found significant in the film response at a frequency below piezoelectric resonance. Diagonal and effective EO coefficients of the (Sr, Ba)Nb2O6 (SBN) film explored in the present work are larger than those of a crystal of lithium niobate (LN) at the same wavelength lambda=633 nm.