Table 8 Predictors of mortality Selleck PLX3397 according to univariate and multivariate logistic regression analysis Independent (Predictor) Variable Survivors (N/%) Non-survivors (N/%) Univariate analysis Multivariate analysis               O.R. P -value Age                 ≤ 40 77(79.4) 22(22.6)             > 40 5 (71.4) 2(28.6) 1.23 0.24-2.98 0.984 2.32 0.43-2.45 NS Sex                 Male 58 (77.3) 17(22.7)             Female 22 (75.9) 7 (24.1)

2.21 0.95-2.76 0.051 1.32 0.22-2.32 NS Duration of illness                 Within 14 days 64 (76.2) 20 (23.8)             After 14 days 16 (80.0) 4 (20.0) 1.11 0.57-1.98 0.454 1.67 0.78-2.11 NS Perforation-admission interval            

    Within 24 hours 15 (93.7) 1 (6.3)             After 24 hours 65 (73.7) 23 (26.1) 2.43 1.34-3.54 0.024 1.67 1.12-3.43 0.003 Timing of operation                 Within 24 hours 12(85.7) 2(14.3)             After 24 hours 68 (75.6) 22(24.4) 0.21 0.11-0.98 0.011 1.23 1.12-3.65 0.034 HIV status                 Positive 3 (33.3) 6(66.7)             PF-6463922 order Negative 63 (79.7) 16 (20.3)             Not known 14 (87.5) 2 (12.5) 3.54 2.46-4.98 Wortmannin research buy 0.031 0.23 0.11-0.98 0.022 CD4+ count (cells/μl)                 ≤ 200 1(33.3) 2 (66.7)             > 200 3(75.0) 1(25.0) 5.34 3.45-6.98 0.004 4.54 3.23-6.87 0.000 Prehospital antibiotic therapy                 Adequate 23 (88.5) 3 (11.5)             Inadequate 52 (72.2) 20 (27.8)             Not documented 7 (87.5) 1 (12.5) 2.87 2.11-4.50 0.021

3.11 1.45-7.86 0.006 ASA classes                 I-II (Low risk group) 26 (92.9) 2 (7.1)             III-V (High risk group) 54 (71.1) 22 (28.9) 0.32 0.11-0.98 0.033 else 3.2 2.34-6.81 0.012 SBP on admission                 ≤ 90 mmHg 22 (61.1) 14 (38.9)             > 90 mmHg 58(85.3) 10 (14.7) 3.45 1.56-4.91 0.011 1.98 1.72-4.98 0.000 Type of peritonitis                 Generalized 74(77.1) 22 (22.9)             Localized 6(75.0) 2(25.0) 1.95 0.98-2.75 0.967 0.32 0.11-1.63 NS Amount of peritoneal fluid/pus                 ≤ 1000 mls 13 (86.7) 2 (13.3)             > 1000 ml 67(75.3) 22 (24.7) 1.52 1.18-2.22 0.023 1.22 1.09-1.76 0.011 Number of perforations                 Single 71 (80.7) 17 (19.3)             Multiple 9 (56.2) 7(43.8) 1.54 1.11-4.87 0.012 2.89 2.33-5.98 0.007 Postoperative complications                 Present 25 (61.0) 16 (39.0)             Absent 55 (87.3) 8 (12.7) 2.98 2.33-4.91 0.004 5.22 3.43-6.94 0.000 Keys: N = Number of patients, C.I.