One of the most adequate and brief terms for “”carcinoid”" that is included now in the group of GEP-NETs (gastroenteropancreatc neuroendocrine tumors) or simply NETs [8, 16, 17] would be “”endocrinocarcinoma”" [18–21], followed by NEC (neuroendocrinocarcinoma) or GEC (gut endocrinocarcinoma). Table 2 the term “”Carcinoid”" Evaluation Authors Year Reference Unfortunate Willis RA 1940 [4] Misleading Roberts TW 1958 [5] Outmoded Wick MR, et al 1988 [6]   Klemm KK, et al 1999 [7] Archaic Modlin IM, et al 1997 [8]   Modlin IM 2005 [9] Confusing Andrés R 2002 [10] Misnomer Soga J 1973 [11]   Rowe LD 1979 [12] Epigenetics Compound Library order   Moertel CG 1987 [13]   Soga J, et al 1999 [14]   Soga J 2003

[15]   Soga J 2005 [3] On the other hand, since the term “”carcinoid”" has been so attractive and popularly used on a worldwide scale, and will be alive in the future for searching systems such as PubMed or Index Medicus, it would be very difficult and inconvenient to eliminate this term in a short period of time. Meanwhile this term and a newly accepted term, Poziotinib if decided, should be interchangeable with each other for the purpose of automated searching: for a concrete example, the new term with carcinoid in parentheses: [endocrinocarcinoma (carcinoid)....]. Most important is that the term “”carcinoid”" should be used for

a certain number of years, at least during the present generation of more or less 50 years, in the author’s estimation, and be described without L-NAME HCl an adjective “”benign”" or “”malignant”" in recognition of the real entity of this particular malignant tumor group. Then, the necessity of the term “”carcinoid”" might be discussed by the next generation concerning its usefulness in automated searching for the literature. No “”benign”" carcinoid without local invasion has been available up to this date either in the digestive organs or extradigestive sites in the author’s experience. Only complete serial sections of a seemingly encapsulated lesion could prove the benignancy, if any, with definite confirmation for the absence of a break of the capsule by microinvasion or budding. This would be, however, practically impossible. The histologic patterns or classification [11,

14] would be still well applicable to “”endocrinocarcinoma”" as an initial morphologic implication for diagnosis. The adequate term should be globally and historically discussed on several proposals along with future problems in relation to the real entity of this tumor group, considering the evaluation of the Consensus Conference [17]. Changes in concepts of “”carcinoid”" It is extraordinarily courageous to coin a new concept of tumor entity, as did Oberndorfer, a 31-year-old enthusiastic young scientist at that time in the year 1907 [1], and similarly to criticize a well-established and world-widely accepted concept introduced even in the textbooks. However, a change corrected on the basis of the truth is always required in science.