For symptom assessment, the Edmonton Symptom Assessment Scale (ESAS)

is used [26]. The ESAS is a validated nine-item patient-rated symptom visual analogue scale developed for use in assessing the symptoms of patients receiving palliative care. The single item depression of the ESAS can reliably screen for depression as measured by more in depth instrument [27]. From published lists of frequent symptoms the study team selected 21, a number considered both feasible to be utilized in practice and comprehensive enough [28]. As next step the E-MOSAIC software was developed, piloted and refined with professionals and #GABA antagonist drugs keyword# patients resulting in the palm-based assessment E-MOSAIC (Figure1). Figure 1 Screenshot from Palm as illustration. The palm-based assessment consists of three elements Inhibitors,research,lifescience,medical (see screenshots in the Appendix), which are filled out by the patient (element P) and the study personnel (elements

G [weight] and M [medication]). Element P Visual-Analogue Scales (VAS) of 1. Nine frequent symptoms from ESAS (pain, fatigue, drowsiness, nausea, anxiety, depression, shortness of breath, loss of appetite, overall well-being); For E-MOSAIC the single symptoms of the original ESAS were translated in German, French and Italian language in an informal back- and forward process, and validated preliminarily. ESAS Inhibitors,research,lifescience,medical is measured by palm in all patients. 2. Up to three optional symptoms; 3. Patients’ Inhibitors,research,lifescience,medical estimated nutritional intake. Element G: 1. Body weight; 2. Karnofsky Performance Status; 3. Weight loss and body height (Body Mass Index calculated automatically). Element M: pre-defined, simplified list for actual medication for: 1. Pain syndromes, including Inhibitors,research,lifescience,medical assessment of MEDD (Morphin Equivalent [oral] Daily Dose); 2. Fatigue syndromes (Methylphenidate, Erythropoietin, transfusions); 3. Anorexia/cachexia syndromes, and for edema (to control for weight changes). After completion of the assessments the palm is put back to the docking station and the data are transferred

within a few seconds from the docking station to the local computer. The source-code of the E-MOSAIC software is copy-protected. The software is study-specific, STAT inhibitor but may be used for other purposes. Longitudinal Monitoring Sheet LoMoS which is printed immediately and put in the patient file for the physicians’ visit by the nurse (Figure2). Figure 2 Longitudinal monitoring Sheet: LoMoS. Structure of LoMoS: 1. VAS pain, pain medication (opioids calculated as morphine-equivalent daily dose; other analgesics); 2. VAS fatigue, KPS, medication for fatigue (Methylphenidate, Erythropoietin); 3. VAS anorexia, VAS perceived nutritional intake, weight change, medication for anorexia (nutritional counselling, progestins, prokinetics); 4. 6 ESAS symptoms 5. Maximal 3 of 21 symptoms selected by patient at baseline.