Conclusion: Strong association between physiological levels of serum BA and body mass index was observed in healthy subjects. BA determination within the physiological concentration range (hsBA) seems to reflect the overweight status. Clinical studies on patients with diabetes and metabolic syndrome are needed to assess the role of hsBA as a possible marker or predictor of these conditions. Supported by a grant NT13151-4 given by the Czech Ministry of Health. Key Word(s): 1. bile acids; 2. overweight; EX 527 research buy 3. obesity; 4. body mass

index Presenting Author: AHMAD NAJIB AZMI Additional Authors: KHEAN LEE GOH Corresponding Author: AHMAD NAJIB AZMI Affiliations: University of Malaya Objective: We report a case of advance, inoperable Barcelona Clinic Liver Cancer (BCLC) C hepatocellular carcinoma with CP score A that survives following Sorafenib therapy. Methods: A 63-year-old woman presented with complaint of vague abdominal pain, nausea, fatigue and general malaise for 1-month duration. She was not known to have viral hepatitis nor any liver disease prior to this. Clinically she appeared very lethargic. She was not pale nor jaundice. Abdominal examination revealed enlarged liver, 6 cm below

the costal margin and no ascites. Results: Blood investigations showed hemoglobin 16 g/dl, platelet 200 x 10 9 IU/ml, total bilirubin 18 umol/L, albumin 40 g/L, alanine aminotransferase 71 IU/L, international normalization ratio (INR) Gefitinib mw 1.1, alpha-fetoprotein (AFP) 101,506 IU/L and anti-HCV antibody was positive. CT liver 5-phase revealed a right lobe liver lesion (segment V & VIII) measured 7.5 x 8.0 cm consistent with HCC, no portal vein thrombosis. Surgery and radiofrequency ablation was not possible. Trans-arterial chemo-embolization was offered but patient did not keen to proceed. Sorafenib was

initiated at 400 mg twice daily. She developed several side effects; low-grade fever but later subsided, minimal rash on and off and diarrhea, 上海皓元 which were controlled with medication. AFP level at week 10, 12, 16 and 32 dropped tremendously to 652, 206, 19 and 5 respectively. CT liver 5-phase at week 24 showed complete tumor necrosis with evidence of complete response. Subsequent follow-up CT scan up to 4 years since Sorafenib was initiated showed stable disease with no evidence of recurrence and AFP remain below 3 IU/L. She is currently asymptomatic with good performance status. She received a total 30 weeks of Sorafenib treatment. Conclusion: Sorafenib is a multi-kinase inhibitor, which is effective in advance HCC.