Ascorbic acid has been shown for being cytotoxic to MCF seven and HT 29 cells and to induce cell death by means of the generation of H2O2. Generation of oxidative strain due to H2O2 is connected using the arrest of cancer cell proliferation and triggering of apoptosis. Ascorbic acid has been reported to in duce cell cycle arrest with the G2 M phase and miti gate tumor metastasis. We observed similarities during the anticancer results of ascorbic acid reported in litera ture with people exhibited by the ethyl acetate extract of C. sativum root on this examine. Supported by literature and through the final results of our examine, we postulate that as corbic acid contributed for the anticancer and antioxi dant pursuits of C. sativum root observed on this study.
Having said that, the function on the other compounds reported inside the root should not be disregarded since the mixture of compounds in an extract and their probable additive or synergistic action might be accountable for that bioactiv ities produced by an CUDC-101 structure extract. Although the anti proliferative result of the root extract was not incredibly large, regular addition of C. sativum inside the diet program could contribute to total overall health and wellness and secure towards conditions like cancer. Conclusion The ethyl acetate extract of C. sativum root has antioxi dant and anticancer properties. C. sativum root inhibited DNA damage in fibroblasts and prevented MCF seven breast cancer cell migration induced by H2O2, suggesting its potential in cancer prevention and inhibition of metasta sis.
The herb exhibited anticancer exercise in MCF 7 breast cancer cells by affecting antioxidant enzymes leading to H2O2 accumulation, cell cycle arrest on the G2 M phase and apoptotic cell death by the death receptor and mito chondrial apoptotic pathways. We report the presence of ascorbic acid in C. sativum root, a compound popular for its antioxidant and anticancer properties. Taken selleck chemicals to gether, we showed that C. sativum root has medicinal value with regard to its antioxidant and anticancer correct ties in stopping oxidative worry related ailments and might be beneficial as foods or dietary supplements employed in combin ation with standard drugs to enhance the remedy of conditions this kind of as cancer. The scientific study corroborates the use of this herb in conventional medicine. Background In recent times, pure solutions and medicines have been designed as cosmeceutical substances to resolve esthetic skin complications such as skin darkening and wrin kle.
Artocarpus species, such as A. heterophyllus, A. lakoocha, A. communis, are Asian or Pacific tree crops which are generally utilised in agriculture, common medi cine, and marketplace. Artocarpus species have already been shown to possess numerous pharmacological properties, which incorporate anti inflammatory, tyrosinase inhibitory, antitumorigenic, antidiabetic, antibacterial, antitubercular, antiviral, antiplatelet, and antioxidant activity.