5%) moderate (F2), 29

(24.2%) severe (F3), and 24 (20.0%) had liver cirrhosis (F4). Conclusions: In this study, a high proportion of HIV-HCV co-infected patients Erlotinib mw have chronic HCV infection. HCV GT 1 was found in 40% of patients, the favorable IL28B CC genotype is most common, and 67% of patients have a liver fibrosis indicating the need for treatment. Disclosures: Nicolas Durier – Grant/Research Support: ViiV Healthcare Kiat Ruxrungtham – Advisory Committees or Review Panels, Merck, TIBOTEC, Merck, TIBOTEC, Merck, TIBOTEC, Merck, TIBOTEC; Grant/Research Support: Boehringer Ingelheim, Gilead, Roche, TIBOTEC, Boehringer Ingelheim, Gilead, Roche, TIBOTEC, Boehringer Ingelheim, Gilead, Roche, TIBOTEC, Boehringer Ingelheim, Gilead, Roche, TIBOTEC; Speaking and Teaching: Abbott, Bristol-Myers Squibb,

GlaxoSmithKline, J&J, Abbott, Bristol-Myers Squibb, GlaxoSmithKline, J&J, Abbott, Bristol-Myers Squibb, GlaxoSmithKline, J&J, Abbott, Bristol-Myers Squibb, GlaxoSmithKline, J&J Gail Matthews – Advisory Committees or Review Panels: gilead; Consulting: Viiv; Grant/Research Support: Gilead Sciences, janssen; Speaking and Teaching: BMS, MSD The selleck chemicals following people have nothing to disclose: Anchalee Avihingsanon, Kinh Nguyen Van, Bui Vu Huy, Evy Yunihastuti, Andri S. Sulaiman, Sharifah Faridah binti Syed Omar, Ilias Adam Yee, Patricia Morgan, David Boettiger Introduction: 25-hydroxyvitamin D [25(OH)D] level has been associated with advanced liver fibrosis in chronic hepatitis

C virus (HCV) infection. Liver stiffness measurement (LSM) via transient elastography is well validated for assessing fibrosis in chronic HCV. Therefore we assessed any association between LSM and 25(OH)D level and identified predictors medchemexpress of 25(OH) D level in a prospective cohort of patients with chronic HCV infection. Methods: 209 consecutive HCV PCR positive patients attending a dedicated hepatitis C clinic at a tertiary referral center between October 2011 and October 2013 were formally interviewed. Data on duration of infection, alcohol and recreational drug use was prospectively collected, and routine blood tests including 25(OH)D levels obtained. LSM by Fibroscan® was obtained as part of routine care. Predictors of LSM and 25(OH)D level were identified. Results: Mean age of the cohort was 46 ± 10 years with 121 (58%) male. Mode of infection was injecting drug use in 73%, while duration of infection was >20 years in 60%. HCV genotype distribution was: G1 57.4%, G2 4.3%, G3 35.9%, and 2.4% other. Mean 25(OH)D level was 69.7 ± 33.5 nmol/L with vitamin D deficiency (<50 nmol/L) present in 30%. Predictors of 25(OH) D level on multivariate analysis included season (P<0.0001), gender (P<0.0001), INR (P=0.001), and vitamin D supplementation (P=0.04). Median LSM was 6.2 kPa, with 38.7% and 16.5% having an LSM >7.65 kPa and >13.0 kPa respectively. 9.6% of patients used vitamin D supplementation and 34.9% were assessed during Summer/Autumn months.