The rates of animals with lung metastases were re duced from 100. 0% in the Control group to 63. 6% in the DOX group and 33. 3% in the PDOX Bosutinib group. PDOX had higher inhibitory effect on tumor proliferation than DOX IHC studies were performed to investigate the expression of major cancer molecules possibly affected by the treat ments. As shown in Table 2 and Figure 2, positive cyto plasmic Cat B expression was observed in all tumors from the 3 groups. Ki 67 positive rates were 77. 17. 8% in the Control group, 72. 34. 9% in the DOX group, and 61. 614. 6% in the PDOX group. The median MVD values of CD34 were 47. 2 in the Control group, 60. 9 in the DOX group, and 55. 6 in the PDOX group, respectively. The VEGF positive rate was not statistically different among the 3 groups.

Similarly, there was no statistical difference in the expression of E cadherin among the 3 groups. Inhibitors,Modulators,Libraries Inhibitors,Modulators,Libraries The median values of Inhibitors,Modulators,Libraries LMVD designated as D2 40 positive expression were 0. 5, 1. 8 and 1. 8 in the Control, DOX and PDOX groups, respectively. PDOX had less hematological and biochemical toxicities than DOX The hematological and non hematological toxicities were studied. In peripheral blood routine, the white blood cells levels in PDOX mice were higher than DOX mice. The platelet levels were higher in the PDOX group and the DOX group compared with Control. There were no differences in red blood cells and hemoglobin levels among the 3 groups. In terms of liver functions, compared with Control, DOX and PDOX caused significant reduction in GGT and AST levels.

Inhibitors,Modulators,Libraries There were no statistically significant differ ences in AST, TBIL and DBIL levels among the 3 groups. In terms of renal functions, compared with Control, both DOX and PDOX resulted in significant reduction in serum BUN levels, and BUN levels in the PDOX group were also significantly Inhibitors,Modulators,Libraries lower than those in the DOX group. Furthermore, the serum Cr levels in the PDOX group were much lower than those of the Control and DOX groups. Electrolytes results demonstrated that Cl was reduced in PDOX compared with Control group. But Ca2 was increased in PDOX compared with the Control and DOX groups. PDOX had less cardio toxicity than DOX Cardiac functions demonstrated that both DOX and PDOX significantly decreased LDH compared with Control group. but there were no differences between the DOX and PDOX groups. Com pared with Control, DOX increased CK and CK MB levels, although the differences didnt reach the statistical significance. On the other hand, PDOX significantly de creased CK, compared with DOX. Histopathological study revealed multiple spotty de generative changes in the myocardium in DOX treated mice. There were no observable histopathological changes sellekchem in both Control and PDOX groups.