Sometimes WHO representatives may also participate in the working

groups. After assessing all available data, the committee will reach consensus and recommendations will be made. If consensus proves impossible, the matter will be sent to the MoH, to make the final decision. Agreed Target Selective Inhibitor Library recommendations are forwarded to the ultimate decision-makers within the MoH and then widely circulated via circulars and newsletters. It should be noted that to date the committee has always followed official WHO recommendations for vaccine use. Formal contact between the committee members and similar NITAGs in the Gulf Cooperation Council (GCC) countries is facilitated through an annual inter-country Selleckchem Dolutegravir meeting on communicable diseases that includes all the countries of the GCC. This comprises Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, the United Arab

Emirates and Yemen. Half of the meeting each year is devoted to discussing issues concerning the Expanded Programme on Immunization (EPI), including the introduction of new vaccines and immunization issues. In 2007, it was recommended that GCC countries would have a common EPI schedule, a decision validated by all NITAGs in GCC countries and then approved by the relevant Ministers. As of 1 January 2008, the decision was implemented. The cost of vaccines, as well as that of the overall immunization program, is considered when the committee decides on its recommendations. Formal economic evaluations are made (cost-effectiveness, cost-benefit and cost-utility) and both affordability and sustainability are assessed. Subcommittees, with the assistance of health economic experts from within the MoH, assist in making these evaluations—for example, an economic evaluation of rotavirus vaccine disease burden was undertaken. They are currently assessing the human papillomavirus (HPV) disease burden from an economic

perspective. Additionally, assessments made regionally are taken into account, particularly when provided by WHO’s Eastern Mediterranean Regional Office (EMRO) or from other GCC countries, such as in the case of cost-effectiveness studies on HPV. Recommendations are circulated to all members to receive their comments, after which they are sent those to decision-makers for final approval. The Government is obliged to implement committee recommendations. The Ministry of Finance and other government departments play no part in decision-making. A good example of how decisions are made can be found in the case of the introduction of PCV-7 into the EPI schedule in Oman. At the time, there was very strong demand from the vaccine committee members and paediatricians to introduce the vaccine. As a result, the committee recommended forming a task force to study the disease burden and the vaccine’s cost-effectiveness.