Multivariate Cox proportional hazards survival analysis showed that age and sex were not significant predictors of patient or graft outcomes. Neither race nor duration of time on dialysis influenced outcomes in Imatinib solubility the PD versus HD subanalysis (P = 0.73 and 0.88, resp.). In the multivariate analysis, DGF but not dialysis modality was a significant variable for patient and graft survival (P = 0.002). Figure 1 Graft (a) and patient survival (b) curves in peritoneal (PD) and hemodialysis (HD) groups. By Mantel-Cox log rank test, there was no difference in graft (P = 0.51) or patient (P = 0.52) survival. Figure 2 Graft (a) and patient (b) survival curves in African American subgroup with pretransplant peritoneal (PD) and hemodialysis (HD). By Mantel-Cox log rank test, there was no difference in graft (P = 0.

46) or patient (P = 0.3) survival. Table 2 Dialysis modality and renal transplant outcomes. The complications Inhibitors,Modulators,Libraries during the first year after renal transplant are shown in Table 2. The incidence of DGF was significantly lower in the PD group compared to the HD group (17.7% versus 38.8%, P < 0.005). We did not find any significant difference in the incidence of arterial or venous thrombosis, Inhibitors,Modulators,Libraries systemic or local wound infections, or acute rejections episodes between the two groups. 4. Discussion To our knowledge, this is the first single-center study to compare the outcomes of prerenal transplant peritoneal to hemodialysis in a predominantly African American population. While most reports from the United States had only 20�C30% African American patients [3, 6, 12, 13], 73% of our renal allograft recipients were African Americans.

We have shown that long-term graft survival is independent of the modality and duration of dialysis. Patients on pretransplant Inhibitors,Modulators,Libraries PD had a significantly lower rate of DGF, and there was no increased risk of graft vascular thrombosis or infectious complications. Since PD has been shown to be more cost-effective and reduce Inhibitors,Modulators,Libraries rehospitalization rates [14] in addition to preserving residual renal function [15], there is a renewed interest to promote this dialysis modality for ESRD patients in United States. While some studies have failed to find a difference in outcomes [12, 16�C18], others have found PD to have beneficial effects after renal transplantation compared to HD [1, 13, 19].

Our findings are similar to the studies [3, 13, 19] that have shown PD to have a protective effect on lowering the rate of DGF. In our Inhibitors,Modulators,Libraries study, the HD and PD groups were well matched for most donor and recipient characteristics with 75% and 63% African American patients, respectively. Patient survival was similar in the two groups. In the multivariate analysis, DGF was the only factor with a significant impact on graft survival. Due to the relatively Drug_discovery small sample size of this study, age and sex matching the two comparison groups would be underpowered.