Materials and methods: PubMed and Embase were searched for relevant articles. We calculated sensitivities, specificities, diagnostic odds ratios (DOR), positive likelihood ratios (PLR), negative likelihood Angiogenesis inhibitor ratios (NLR), and constructed summary receiver operating characteristic curves using bivariate models for whole-body MRI and skeletal scintigraphy, respectively.
Results: Across 7 studies (332 patients),
whole-body MRI have similar patient-based sensitivity (0.84 vs 0.83), specificity (0.96 vs 0.94), DOR (137.0 vs 70.2), PLR (23.3 vs 13.0) and NLR (0.17 vs 0.19) with skeletal scintigraphy. Area under curves for whole-body MRI and skeletal scintigraphy was 0.94 and 0.89, respectively.
Conclusion: Both whole-body MRI and skeletal scintigraphy have good diagnostic performance for detecting bone metastatic tumors. It remains inconclusive whether whole-body MRI or bone scintigraphy is superior
in detecting bone metastatic tumors. (C) 2013 Elsevier Ltd. All rights reserved.”
“Approximately 1 year after rats were seized as young adults with lithium (3 mEq/kg) and pilocarpine (30 mg/kg) and given acepromazine or ketamine, 18 blood measures, wet tissue weights, and detailed damage scores for 107 brain structures were completed. Compared with normal and ketamine-treated rats, acepromazine-treated seized rats (total n = 54) had lighter pancreata and spleens and elevated aspartate aminotransferase and alanine aminotransferase blood levels. Even though average damage did not differ, the mosaic of brain PARP signaling damage completely discriminated the two seized groups. Differential effects of postseizure treatment on functions of the thyroid, pancreas, and spleen were www.selleckchem.com/products/MK-2206.html indicated. Ketamine-treated seized rats were healthier than acepromazine-treated seized rats or normal rats. This experiment demonstrates the importance of whole-organism assessment and that the single administration of a specific drug after onset of status epilepticus can produce marked differences in the evolution of brain damage
and its influence on specific organs for the rest of the animal’s life. (C) 2009 Elsevier Inc. All rights reserved.”
“Study Design. Use of magnetic resonance imaging (MRI) with Constructive Interference in Steady State (CISS) sequence and isometric voxels to demonstrate the anatomic variations of vertebral artery in C2 vertebra.
Objectives. To determine the transarticular screw trajectory on CISS MRI and to identify patients with anatomic variations of vertebral artery in C2 vertebra.
Summary of Background Data. Atlantoaxial transarticular screw fixation has been reported to be biomechanically superior to other posterior techniques for atlantoaxial arthrodesis. Vertebral artery injury can be associated with catastrophic sequelae.