51, p < .001, β = −.36, R2 change = .09, ƒ2 = .10, with higher scores in mindfulness being related to lower current depression. Finally, to test the interaction between neuroticism and mindfulness, the product of centered EPQ neuroticism and centered FFMQ sumscores was entered as an additional predictor in the third step. In line with our hypothesis, the interaction between neuroticism and mindfulness emerged as a significant predictor, t = −2.49, p = .01, β = −1.00, R2 change = .03, ƒ2 = .03. Fig. 1 illustrates the interaction by depicting the regression lines of the relation between neuroticism and current depression at high, medium and low (+1 SD, mean, −1 SD) scores of the FFMQ sumscore scale. Decreases in the

slope of the regression line with increasing mindfulness scores show that the relation between neuroticism

and current symptoms of depression becomes weaker with higher levels of dispositional mindfulness. In order to further characterize Panobinostat cost the nature of this interaction we used the Johnson–Neymann (J–N) technique (following suggestions and using the SPSS script provided by Hayes & Matthes, 2009). The J–N technique allows to directly identify points in the range of the moderator variable where the effect of the predictor on the outcome transitions from being statistically significant to nonsignificant by finding the value of the moderator variable for which the ratio of the conditional effect to its standard error is equal to the critical t score. The conditional Digestive enzyme effect of neuroticism on current depression transitioned in significance http://www.selleckchem.com/products/Cyclopamine.html at a FFMQ sumscore of 145.51, b = .30, SE = .15, t = 1.97, p = .05, 95% CIs [.00, .60], at the 90th percentile of the distribution in our sample, with the relation between EPQ neuroticism and BDI-II scores significant at FFMQ sumscores below this threshold and nonsignificant at FFMQ sumscores above this threshold. In order

to further investigate which components of mindfulness skills were most relevant in moderating the effects of neuroticism on current depression, we repeated the above analyzes separately with all five subscales of the FFMQ. After adjusting α-levels for familywise error rate to α = .01, none of the interactions were significant. The only interaction that approached significance was for the Describing subscale, interaction neuroticism by FFMQ Describing: t = −2.88, p = .02, β = −.66, R2 change = .02, f2 = .03. Probing this effect using the J–N technique showed that significance at the .05 level transitioned at a score of 37.01, b = .40, SE = .20, t = 1.97, p = .050, 95% CIs [.00, .80], the 93rd percentile of the distribution in our sample with the pattern of the effect following that of the effect for the FFMQ sumscore, i.e. the conditional effect of neuroticism on current depression being significant below and nonsignificant above the threshold. As most of the subscales of the FFMQ are moderately intercorrelated (intercorrelations in our sample ranged from r = .08 to .