A previously healthy 4-month-old girl presented with a bleeding scalp hemangioma, a bulging fontanel, and anemia. Magnetic resonance imaging (MRI) Cl-amidine price of the brain revealed hydrocephalus along with multiple intracranial hemangiomas. These lesions compressed the jugular foramina, resulting in venous sinus thrombosis involving the right transverse sinus, the left sigmoid sinus, and the torcular herophili. The patient had no family history of phakomatoses or other genetic
abnormalities. A thrombophilia work-up result was unremarkable. The patient was treated with prednisolone (10 mg twice daily) and low molecular weight heparin (1 mg/kg/dose) twice daily. This treatment decreased the size of her cutaneous and intracranial hemangiomas and led to the resolution of her venous sinus thromboses and hydrocephalus. Innocuous scalp
hemangioma in an infant may herald more concerning intracranial pathology, which can be treated effectively buy LY3039478 if diagnosed with appropriate imaging studies.”
“A stress-biased magnetoelectric sensor with a built-in permanent magnet has been fabricated using piezoelectric lead magnesium niobate-lead titanate single crystal and magnetostrictive Terfenol-D alloy. The resonance characteristics and magnetoelectric performance of the sensor have been evaluated under different stress-biased conditions. The resonance of the sensor shifts to higher frequency with increasing preloading stress. Due to the piezoelectric and magnetostrictive enhancements under preload, the device exhibits a giant magnetoelectric voltage coefficient of 0.22 V/Oe at a preloading stress of
2.5 MPa. This compact device has the potential to be used as a standalonesensor without requiring external power input. (C) 2011 American Institute of Physics. [doi:10.1063/1.3536636]“
“Purpose: To determine the PF-03084014 feasibility of T2-weighted magnetic resonance (MR) imaging in the noninvasive quantification of renal inflammation by using superparamagnetic iron oxide (SPIO) nanoparticles targeted to tissue-bound C3 activation fragments in a mouse model of lupus nephritis.
Materials and Methods: All animal procedures were approved by the University of Colorado-Denver animal care and use committee. SPIO nanoparticles were encapsulated by using amine-functionalized phospholipids. A recombinant protein containing the C3d-binding region of complement receptor type 2 (CR2) was then conjugated to the surface of the SPIO nanoparticle. Five MRL/lpr mice (a model of lupus nephritis) and six C57BL/6 wild-type mice were assessed with T2-weighted MR imaging at baseline and after SPIO injection. The same five MRL/lpr mice and three C57BL/6 mice also underwent MR imaging after injection of CR2-targeted SPIO.