3417 with P = 0.0397. The remaining one cluster has 2 voxels with peak MNI coordinate being (27, −15, 6) and one cluster contains 1 voxel with MNI coordinate being (27, 18, −6). Comparisons on various statistics After locating source subregions of the hate circuit, the voxel-wise time series, that is, the averaged time series over the identified source, voxels within each ROI can be obtained
for further analysis. To compare the Rapamycin mouse ROI-wise time series and the voxel-wise time series in analyzing the two links SFGdor–INS and INS–PUT, for each subject, we plot the correlation coefficients of the two functional connectivity (SFGdor–INS and INS–PUT) using the ROI-wise data and the voxel-wise Inhibitors,research,lifescience,medical data, respectively (see Fig. Fig.3A).3A). It can be seen that the correlation coefficients of these two links calculated using ROI-wise data are slightly higher than those obtained using the voxel-wise
data both for patients and controls. This observation indicates the reduction of the coherence Inhibitors,research,lifescience,medical of activity among the three source subregions. Figure Figure3B3B plots the difference of mean correlation coefficients (DOC) between the normal controls and the patients. It is clear that the difference obtained from voxel-wise data Inhibitors,research,lifescience,medical is much larger than that from ROI-wise data for both links, which indicates that more significant changes can be detected using the voxel-wise data. Figure 3 (A) Plot of the correlation coefficient of ROI-wise data and voxel-wise data for SFGdor–INS link and INS–PUT link. (B) Difference of mean correlation coefficients Inhibitors,research,lifescience,medical between normal controls and patients.
It is clear that the difference of … Now we analyze the effect of these two links using both ROI-wise data and voxel-wise data, with the results being listed in Table Table3.3. For SFGdor–INS link, the ROI-wise data have an odds ratio of Inhibitors,research,lifescience,medical 0.1270 with P = 0.0598, while voxel-wise data have an odds ratio of 0.1484 with P = 0.0009, which is far more significant than that from ROI-wise data. For the absolute measure of effect, the ROI-wise data have a risk difference of −0.1525 with P = 0.03 (permutation Linifanib (ABT-869) test), while voxel-wise data have a much greater risk difference of −0.3777 with P-value being almost zero. Similarly, for INS–PUT link, the ROI-wise data have an odds ratio of 0.5139 with P = 0.5934, which is no longer significant. But for voxel-wise data, the corresponding odds ratio is 0.0556 with P = 0.0069, which is significant. For the absolute measure of effect, the ROI-wise data have a risk difference of −0.0243 with P = 0.6180 (permutation test), while voxel-wise data have a much greater risk difference of −0.3063 with P approaching zero. Table 3 Different measures of effect on SFGdor–INS link and INS–PUT link with ROI-wise and voxel-wise data ALFF After band-pass filtering (0.01–0.